For Healthcare Professionals Login to the Nplate® NEXUS Program
Nexus Nplate<sup>®</sup> (romiplostim)
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Welcome to Nplate® (romiplostim) NEXUS
The Nplate® NEXUS Program Connects You With Nplate® Access, Support, Education, and Safety Monitoring.
Amgen is committed to encouraging quality patient care. The Nplate® NEXUS program is designed to facilitate provider education and monitor safety to assure quality patient care.


Nplate® is indicated for the treatment of thrombocytopenia in patients with chronic immune (idiopathic) thrombocytopenic purpura (ITP) who have had an insufficient response to corticosteroids, immunoglobulins
or splenectomy.

Nplate® should be used only in patients with ITP whose degree of thrombocytopenia and clinical condition increases the risk for bleeding. Nplate® should not be used in an attempt to normalize platelet counts.


IMPORTANT SAFETY INFORMATION

Serious adverse reactions associated with Nplate® in clinical studies were bone marrow reticulin deposition
and worsening thrombocytopenia after Nplate® discontinuation. Additional risks include Bone Marrow Fibrosis, Thrombotic/Thromboembolic Complications, Lack or Loss of Response to Nplate®, and Hematological Malignancies and Progression of Malignancy in Patients with a Pre-existing Hematological Malignancy or Myelodysplastic Syndrome (MDS).

Nplate® is not indicated for the treatment of thrombocytopenia due to MDS or any cause of thrombocytopenia other than chronic ITP.

Nplate® is available only through a restricted distribution program called Nplate® NEXUS (Network of Experts Understanding and Supporting Nplate® and Patients) Program.

In the placebo-controlled studies, headache was the most commonly reported adverse drug reaction.
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